|
rs2075685
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, our results suggest that XRCC4 rs20</span>75685 polymorphism plays an important role in the risk of pancreatic cancer in a Chinese population, especially in tobacco smokers.
|
26045837 |
2015 |
|
rs2075685
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Logistic regression analysis showed that individuals carrying the TT genotype of XRCC4 rs2075685 had an increased risk of pancreatic cancer compared to those with the GG genotype, with an odds ratio (95% confidence interval) of 1.88 (1.15-3.08).
|
26345895 |
2015 |
|
rs3218536
|
|
|
0.010 |
GeneticVariation |
BEFREE |
XRCC2 Arg188His polymorphism may be one of the genetic modifiers for smoking-related pancreatic cancer.
|
17986315 |
2008 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In the subgroup analysis based on ethnicity, there was no statistically significant association between XRCC1 rs1799782 genetic polymorphism and pancreatic cancer risk in Asians/Caucasians under all genetic models (all P values > 0.05).
|
24435745 |
2014 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Yet only one polymorphism, XRCC1 Arg194Trp, appears to be involved in smoking-related cancers and in early onset pancreatic cancer.
|
17397816 |
2007 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We investigated the association between polymorphisms of MGMT (Leu(84)Phe and Ile(143)Val), APE1 (Asp(148)Glu), and XRCC1 (Arg(194)Trp and Arg(399)Gln) and risk of pancreatic cancer in a case-control study.
|
16844323 |
2006 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The present meta-analysis showed significant associations between deoxyribonucleic acid (DNA) repair gene (X-ray repair cross-complementing group 1 (XRCC1) Arg399GIn and Arg194Trp, excision repair cross complementation 1 (ERCC1) rs11615 and rs3212986, ERCC2 rs13181) polymorphisms and PC risk.
|
31393355 |
2019 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
This study examined the main and interactive effect of 9 single-nucleotide polymorphisms (SNPs) (Arg194Trp, Arg280His, Arg399Gln, c.1254C>T, c.1517G>C, c.1471G>A, C310T, 539del542, and T1915C) of XRCC1 in contribution to pancreatic cancer (PC).
|
26418909 |
2016 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In conclusion, we found that XRCC1 Arg399Gln genetic variations are associated with pancreatic cancer development, whereas the XRCC1 Arg280His and Arg194Trp polymorphisms did not affect pancreatic cancer risk.
|
27323136 |
2016 |
|
rs25487
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, we found that XRCC1 Arg399Gln genetic variations are associated with pa</span>ncreatic cancer development, whereas the XRCC1 Arg280His and Arg194Trp polymorphisms did not affect pancreatic cancer risk.
|
27323136 |
2016 |
|
rs25487
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We investigated the association between polymorphisms of MGMT (Leu(84)Phe and Ile(143)Val), APE1 (Asp(148)Glu), and XRCC1 (Arg(194)Trp and Arg(399)Gln) and risk of pancreatic cancer in a case-control study.
|
16844323 |
2006 |
|
rs25487
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Therefore, the meta-analysis suggests that XRCC1 rs25487 polymorphism is associated with pancreatic cancer</span> risk in Asians.
|
23807675 |
2013 |
|
rs25487
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We observed that the minor allele of rs25487 in XRCC1 was significantly associated with PC risk in the per-allele model (odds ratio = 1.29, CI = 1.01-1.65; trend P = 0.043).
|
22850545 |
2012 |
|
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Results from our stratified analysis based on Hardy-Weinberg equilibrium (HWE) showed that there was a robust significant association between Arg280His polymorphism and pancreatic cancer risk (allelic model, OR 0.743, 95% CI 0.576-0.958, P = 0.022; heterozygous model, OR 0.701, 95% CI 0.525-0.936, P = 0.016; dominant model, OR 0.710, 95% CI 0.537-0.939, P = 0.016).
|
29285737 |
2019 |
|
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, we found that XRCC1 Arg399Gln genetic variations are associated with pancreatic cancer development, whereas the XRCC1 Arg280His and Arg194Trp polymorphisms did not affect pancreatic cancer risk.
|
27323136 |
2016 |
|
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A tendency of association between Arg280His and PC was also detected in the dominant model (OR, 0.70; 95% CI, 0.48-1.00).
|
26418909 |
2016 |
|
rs139599857
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results from this study indicate that the c.1517G>C genetic variant of the XRCC1 gene is significantly associated with PC susceptibility in the Chinese population.
|
25036351 |
2014 |
|
rs2607775
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allelic gene frequency of rs2607775 was higher in PC patients compared with that in the control group (P=0.003).
|
30344718 |
2018 |
|
rs3731055
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 7 XPC tagging SNPs (tag-SNPs) were selected from the International HapMap Project Databases (rs2228001A/C, rs2470353G/C, rs2228000C/T, rs3731114C/G, rs3729587G/C, rs2607775C/G and rs3731055G/A) and were genotyped in 205 patients with PC and 230 non-cancer control subjects using a SNaPshot assay.
|
30344718 |
2018 |
|
rs2470353
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C allelic gene frequency of rs2470353 was higher in patients with PC compared with that in the control group (P=0.003).
|
30344718 |
2018 |
|
rs2228000
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis further revealed that the CCC haplotype of rs2228000, rs3731114 and rs3729587 increased PC risk (odds ratio, 1.610; 95% confidence interval, 1.035-2.481; P=0.034).
|
30344718 |
2018 |
|
rs3729587
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis further revealed that the CCC haplotype of rs2228000, rs3731114 and rs3729587 increased PC risk (odds ratio, 1.610; 95% confidence interval, 1.035-2.481; P=0.034).
|
30344718 |
2018 |
|
rs3731114
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis further revealed that the CCC haplotype of rs2228000, rs3731114 and rs3729587 increased PC risk (odds ratio, 1.610; 95% confidence interval, 1.035-2.481; P=0.034).
|
30344718 |
2018 |
|
rs11644322
|
|
|
0.010 |
GeneticVariation |
BEFREE |
WWOX rs11644322 represents a major predictive factor in gemcitabine-treated pancreatic cancer.
|
26857392 |
2016 |
|
rs1544410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The contingency table analysis indicated that the rs2228570 polymorphisms were correlated with the pathological differentiation of PC significantly, and the rs1544410 polymorphisms were correlated with the TNM classification of PC significantly.
|
25616697 |
2015 |